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    <dc:title>Anisotropic mechanisms for multiphasic unipolar electrograms. Simulation studies and experimental recordings</dc:title>

    <dc:creator>Colli Franzone, Piero</dc:creator>

    <dc:creator>Guerri, Luciano</dc:creator>

    <dc:creator>Pennacchio, Micol</dc:creator>

    <dc:creator>Taccardi, Bruno</dc:creator>

    <dc:date>1999-09-30</dc:date>

    <dc:description>The origin of the multiple, complex morphologies observed in

unipolar epicardial electrograms, and their relationships with myocardial

architecture,  have not been fully elucidated. To clarify this problem we

simulated electrograms (EGs) with a model representing the heart as an

anisotropic bidomain with unequal anisotropy ratio, ellipsoidal ventricular

geometry, transmural fiber rotation, epi-endocardial obliqueness of fiber

direction and a simplified conduction system. The electrograms were compared

with those directly recorded from the surface of isolated dog hearts immersed

in a conducting medium. The model accurately reproduced the recorded EG

morphologies for excitation wave fronts that reach the recording sites by

spreading either along or across fibers.The 

origin of the multiple waves that constitute the QRS complex could be better 

understood after splitting the current sources, the potential distributions and

 the EGs into a field component (further subdivided into an axial and a conormal component) and a "reference"  component. The split model provides an explanation of the interaction between the three-dimensional geometry and direction of 

propagation of a spreading wave front, the architecture of the fibers through 

which excitation is spreading, the potential distributions and the QRS wave 

forms. Because epicardial potentials, electrograms and isochrone contours can be

computed noninvasively from body surface measurements, interpreting epicardial 

EGs in terms of intramural events may have clinical relevance.</dc:description>

    <dc:identifier>http://puma.isti.cnr.it/dfdownloadnew.php?ident=cnr.imati/cnr.ian.pv/1999-PP-018</dc:identifier>

    <dc:identifier>http://puma.isti.cnr.it/rmydownload.php?filename=cnr.imati/cnr.ian.pv/1999-PP-018/1999-PP-018.bib%</dc:identifier>

    <dc:identifier>http://puma.isti.cnr.it/rmydownload.php?filename=cnr.imati/cnr.ian.pv/1999-PP-018/1999-PP-018_0.pdf</dc:identifier>

    <dc:identifier>http://puma.isti.cnr.it/rmydownload.php?filename=cnr.imati/cnr.ian.pv/1999-PP-018/1999-PP-018_0.ps</dc:identifier>

    <dc:language>eng</dc:language>

    <dc:source>Preprint ercim.cnr.ian//1999-1151, 1999.</dc:source>

    <dc:subject>Electrograms, bidomain model, reference potential, cardiac potential maps, anisotropic propagation, source splitting</dc:subject>

    <dc:subject>info:eu-repo/classification/msc/78A70,65N30</dc:subject>

    <dr:CobjCategory>0016</dr:CobjCategory>

    <oaf:dateAccepted>1999-09-30</oaf:dateAccepted>

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