D-Net

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		<oaf:pid type="doi">10.1016/j.jmgm.2014.05.002</oaf:pid>

		<dc:title>Anisotropic mechanisms for multiphasic unipolar electrograms. Simulation studies and experimental recordings</dc:title>

		<dc:creator>Colli Franzone, Piero,</dc:creator>

		<dc:creator>Guerri, Luciano,</dc:creator>

		<dc:creator>Pennacchio, Micol,</dc:creator>

		<dc:creator>Taccardi, Bruno</dc:creator>

		<dc:date>1999-09-30</dc:date>

		<dc:description>The origin of the multiple, complex morphologies observed in

			unipolar epicardial electrograms, and their relationships with myocardial

			architecture, have not been fully elucidated. To clarify this problem we

			simulated electrograms (EGs) with a model representing the heart as an

			anisotropic bidomain with unequal anisotropy ratio, ellipsoidal ventricular

			geometry, transmural fiber rotation, epi-endocardial obliqueness of fiber

			direction and a simplified conduction system. The electrograms were compared

			with those directly recorded from the surface of isolated dog hearts immersed

			in a conducting medium. The model accurately reproduced the recorded EG

			morphologies for excitation wave fronts that reach the recording sites by

			spreading either along or across fibers.The

			origin of the multiple waves that constitute the QRS complex could be better

			understood after splitting the current sources, the potential distributions and

			the EGs into a field component (further subdivided into an axial and a conormal component) and a "reference" component. The split model provides an explanation of the interaction between the three-dimensional geometry and direction of

			propagation of a spreading wave front, the architecture of the fibers through

			which excitation is spreading, the potential distributions and the QRS wave

			forms. Because epicardial potentials, electrograms and isochrone contours can be

			computed noninvasively from body surface measurements, interpreting epicardial

			EGs in terms of intramural events may have clinical relevance.

		</dc:description>

		<dc:subject>Electrograms, bidomain model, reference potential, cardiac potential maps, anisotropic propagation, source splitting</dc:subject>

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