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38025
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claudio.at
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</header>
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<metadata xmlns="http://namespace.openaire.eu/">
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<dc:title>Anisotropic mechanisms for multiphasic unipolar electrograms. Simulation studies and experimental recordings</dc:title>
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<dc:creator>Colli Franzone, Piero</dc:creator>
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<dc:creator>Guerri, Luciano</dc:creator>
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<dc:creator>Pennacchio, Micol</dc:creator>
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<dc:creator>Taccardi, Bruno</dc:creator>
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<dc:date>1999-09-30</dc:date>
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<dc:description>The origin of the multiple, complex morphologies observed in
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unipolar epicardial electrograms, and their relationships with myocardial
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architecture, have not been fully elucidated. To clarify this problem we
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simulated electrograms (EGs) with a model representing the heart as an
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anisotropic bidomain with unequal anisotropy ratio, ellipsoidal ventricular
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geometry, transmural fiber rotation, epi-endocardial obliqueness of fiber
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direction and a simplified conduction system. The electrograms were compared
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with those directly recorded from the surface of isolated dog hearts immersed
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in a conducting medium. The model accurately reproduced the recorded EG
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morphologies for excitation wave fronts that reach the recording sites by
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spreading either along or across fibers.The
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origin of the multiple waves that constitute the QRS complex could be better
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understood after splitting the current sources, the potential distributions and
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the EGs into a field component (further subdivided into an axial and a conormal component) and a "reference" component. The split model provides an explanation of the interaction between the three-dimensional geometry and direction of
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propagation of a spreading wave front, the architecture of the fibers through
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which excitation is spreading, the potential distributions and the QRS wave
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forms. Because epicardial potentials, electrograms and isochrone contours can be
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computed noninvasively from body surface measurements, interpreting epicardial
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EGs in terms of intramural events may have clinical relevance.</dc:description>
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<dc:identifier>http://puma.isti.cnr.it/dfdownloadnew.php?ident=cnr.imati/cnr.ian.pv/1999-PP-018</dc:identifier>
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<dc:identifier>http://puma.isti.cnr.it/rmydownload.php?filename=cnr.imati/cnr.ian.pv/1999-PP-018/1999-PP-018.bib%</dc:identifier>
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<dc:identifier>http://puma.isti.cnr.it/rmydownload.php?filename=cnr.imati/cnr.ian.pv/1999-PP-018/1999-PP-018_0.pdf</dc:identifier>
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<dc:identifier>http://puma.isti.cnr.it/rmydownload.php?filename=cnr.imati/cnr.ian.pv/1999-PP-018/1999-PP-018_0.ps</dc:identifier>
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<dc:language>eng</dc:language>
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<dc:source>Preprint ercim.cnr.ian//1999-1151, 1999.</dc:source>
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<dc:subject>Electrograms, bidomain model, reference potential, cardiac potential maps, anisotropic propagation, source splitting</dc:subject>
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<dc:subject>info:eu-repo/classification/msc/78A70,65N30</dc:subject>
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<dr:CobjCategory>0016</dr:CobjCategory>
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<oaf:dateAccepted>1999-09-30</oaf:dateAccepted>
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